Fish Allergy Blood Test

What is Fish Allergy?

Fish allergy is an immune system reaction to proteins found in fish that can cause symptoms ranging from mild skin reactions to life-threatening anaphylaxis. It is caused by the immune system producing IgE antibodies against specific fish proteins like parvalbumin found in codfish, tuna, and salmon. The Food Allergen Profile IgE With Component Reflexes is the most important test for diagnosis because it identifies specific IgE antibodies to multiple fish species.

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What causes fish allergy?

Fish allergy is caused by an abnormal immune response to proteins found in fish, primarily parvalbumin, a calcium-binding protein present in fish muscle tissue. When someone with fish allergy consumes fish, their immune system mistakenly identifies these proteins as harmful invaders and produces IgE antibodies to fight them. This triggers the release of histamine and other chemicals that cause allergic symptoms ranging from mild hives and itching to severe reactions like throat swelling, difficulty breathing, and anaphylaxis.

What is the best test for fish allergy?

The Food Allergen Profile IgE With Component Reflexes is the most important test for fish allergy because it measures specific IgE antibodies to multiple fish species including codfish, salmon, and tuna in a single comprehensive panel. This test detects the presence and levels of IgE antibodies that trigger immediate allergic reactions, helping identify which specific fish you react to. Additional tests like the IgG4 Food Panel III for tuna or IgG4 Food Panel VI for flounder can detect delayed sensitivities by measuring IgG4 antibodies. For children, the Food Specific IgG Allergy Pediatric Panel measures codfish antibodies specifically designed for younger patients.

When should I get tested for fish allergy?

You should get tested if you experience hives, itching, swelling of the lips or face, stomach cramps, nausea, or vomiting within minutes to hours after eating fish. Testing is essential if you have ever had difficulty breathing, throat tightness, dizziness, or a rapid pulse after consuming fish, as these indicate severe allergic reactions. You should also consider testing if you have a family history of food allergies, if you have unexplained skin rashes or digestive issues that worsen after meals containing fish, or before reintroducing fish into your diet after avoiding it.

What are the symptoms of fish allergy?
Fish allergy symptoms typically appear within minutes to two hours after eating fish and range from mild to severe. Mild symptoms include hives, itching, eczema, red or watery eyes, nasal congestion, and tingling in the mouth. Moderate symptoms involve stomach cramps, nausea, vomiting, diarrhea, and abdominal pain. Severe reactions include difficulty breathing, wheezing, throat tightness, swelling of the tongue or throat, rapid pulse, dizziness, loss of consciousness, and anaphylaxis, which is a life-threatening emergency requiring immediate medical attention with epinephrine.
Who is at risk for fish allergy?
People with a family history of food allergies or other allergic conditions like asthma, eczema, or hay fever have a higher risk of developing fish allergy. Children and adults who already have other food allergies are at increased risk. Fish allergy often develops during childhood but can also appear in adulthood, making it different from some food allergies that children outgrow. People who work in seafood processing or restaurant kitchens face higher exposure and potential sensitization. Unlike shellfish allergy, fish allergy affects different people and being allergic to one does not automatically mean you are allergic to the other.
What happens if fish allergy is left untreated?
If fish allergy is left undiagnosed and untreated, you risk repeated exposure to allergens that can trigger increasingly severe reactions. Each allergic reaction has the potential to progress to anaphylaxis, a life-threatening condition that causes difficulty breathing, dangerous drops in blood pressure, and loss of consciousness. Without proper diagnosis, you would not have access to emergency medications like epinephrine auto-injectors that can save your life during severe reactions. Continued exposure can also lead to chronic inflammation, persistent digestive problems, skin conditions, and nutritional concerns if you are unknowingly avoiding fish without proper dietary planning and alternatives.
Can fish allergy be diagnosed with a blood test?
Yes, fish allergy can be effectively diagnosed with blood tests that measure specific antibodies your immune system produces in response to fish proteins. IgE blood tests detect immediate allergic reactions by measuring immunoglobulin E antibodies specific to fish like codfish, salmon, and tuna. IgG and IgG4 blood tests can identify delayed sensitivities and immune responses to specific fish species. Blood tests are safer than skin prick tests for people who have had severe reactions, can be done while taking antihistamines, and provide quantitative results showing the level of antibodies present, which helps assess the severity of the allergy.
How is fish allergy treated?
Fish allergy is primarily treated through strict avoidance of all fish and fish-derived products, including fish sauce, fish oil supplements, and foods cooked in fish oil. Individuals with diagnosed fish allergy should carry an epinephrine auto-injector at all times and know how to use it in case of accidental exposure and anaphylaxis. Antihistamines can help manage mild allergic symptoms like hives and itching. Working with an allergist helps create a personalized emergency action plan, and consulting with a dietitian ensures you get adequate nutrition, particularly omega-3 fatty acids, from alternative sources like flaxseed, walnuts, and algae-based supplements.
How can I prevent fish allergy reactions?
Preventing fish allergy reactions requires carefully reading all food labels, as fish can hide in unexpected products like Caesar dressing, Worcestershire sauce, and some barbecue sauces. Always inform restaurant staff about your allergy and ask about ingredients and cross-contamination risks from shared cooking surfaces and utensils. Avoid buffets and seafood restaurants where cross-contact is common. When grocery shopping, check labels for fish ingredients like anchovies, fish gelatin, and fish protein. Be cautious with Asian cuisine, which frequently uses fish sauce, and always carry your epinephrine auto-injector when dining out or traveling.
What natural remedies help with fish allergy symptoms?
While there is no natural cure for fish allergy, some approaches can help manage mild symptoms after accidental exposure, though they should never replace emergency medical treatment for severe reactions. Quercetin, a natural antihistamine found in apples, onions, and green tea, can help reduce mild allergic responses when taken regularly. Probiotics support immune system balance and gut health, potentially reducing inflammation from food sensitivities. Vitamin C acts as a natural antihistamine and can help with mild symptoms. However, these remedies should only complement, not replace, medical treatment, and anyone experiencing difficulty breathing, throat swelling, or other severe symptoms must use epinephrine and seek emergency care immediately.
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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Food Allergen Profile, IgE With Component Reflexes
Google reviews 505 reviews
$395 $308
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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