Endometrial Cancer Blood Test

What is Endometrial Cancer?

Endometrial cancer is a type of cancer that begins in the lining of the uterus (endometrium). It is caused by hormonal imbalances, particularly elevated estrogen levels relative to progesterone, which stimulate excessive growth of the endometrial lining. The Estrogens (Total), Serum test is the most important test for assessing hormonal risk factors for endometrial cancer.

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What causes endometrial cancer?

Endometrial cancer is caused by hormonal imbalances, particularly when estrogen levels are elevated relative to progesterone levels. High estrogen stimulates the endometrial lining to grow excessively, increasing the risk of cancerous changes. Other contributing factors include obesity, diabetes, polycystic ovary syndrome (PCOS), hormone replacement therapy with estrogen alone, late menopause, never having been pregnant, and certain genetic conditions like Lynch syndrome.

What is the best test for endometrial cancer?

The Estrogens (Total), Serum test is the most important blood test for assessing endometrial cancer risk because it measures estrogen levels that directly influence endometrial lining growth. When combined with the Progesterone test, it provides a complete picture of hormonal balance. Elevated estrogen with low progesterone creates an unopposed estrogen effect that significantly increases cancer risk. While blood tests assess risk factors, definitive diagnosis requires endometrial biopsy and imaging studies. However, hormone testing is essential for identifying women at increased risk who need closer monitoring and preventive measures.

When should I get tested for endometrial cancer?

You should get tested if you experience abnormal vaginal bleeding, especially after menopause, or if you have irregular periods with heavy bleeding. Women taking estrogen-only hormone replacement therapy, those with PCOS, or women who are significantly overweight should consider hormone testing to assess their risk. Additionally, if you have a family history of endometrial or colon cancer, or if you have difficulty getting pregnant or have never been pregnant, hormone level testing can help evaluate your risk factors.

What are the symptoms of endometrial cancer?
The most common symptom of endometrial cancer is abnormal vaginal bleeding, including bleeding between periods, heavier periods than usual, or any vaginal bleeding after menopause. Other symptoms include pelvic pain or pressure, pain during intercourse, unusual vaginal discharge that may be watery or blood-tinged, and unintended weight loss. In advanced stages, you might experience difficulty urinating, pain in the pelvic area, or feeling a mass in the pelvic region.
Who is at risk for endometrial cancer?
Women with hormonal imbalances, particularly those with high estrogen levels and low progesterone, face increased risk. Obesity significantly raises risk because fat tissue produces estrogen. Other risk factors include diabetes, PCOS, taking tamoxifen for breast cancer treatment, estrogen-only hormone replacement therapy, early menstruation before age 12, late menopause after age 55, never having been pregnant, age over 50, and having Lynch syndrome or a family history of endometrial or colorectal cancer.
What happens if endometrial cancer is left untreated?
Untreated endometrial cancer progresses through stages, spreading from the uterine lining to the muscular wall of the uterus, then to nearby organs like the bladder, rectum, and lymph nodes, and eventually to distant organs including the lungs, liver, and bones. Advanced cancer causes severe pelvic pain, significant bleeding leading to anemia, bowel and bladder dysfunction, and can become life-threatening. Early detection through symptom awareness and hormone monitoring dramatically improves treatment outcomes, with over 95% five-year survival rate when caught in early stages.
Can endometrial cancer be diagnosed with a blood test?
Blood tests cannot diagnose endometrial cancer directly, but they play a crucial role in assessing hormonal risk factors. The Estrogens (Total), Serum test and Progesterone test measure hormone levels that influence cancer risk. Definitive diagnosis requires an endometrial biopsy where tissue is removed and examined under a microscope, along with imaging studies like transvaginal ultrasound or MRI. However, blood work helps identify women at higher risk who need closer monitoring and more frequent gynecological examinations.
How is endometrial cancer treated?
Treatment for endometrial cancer typically begins with surgery to remove the uterus (hysterectomy), usually along with the fallopian tubes and ovaries. Depending on the stage and type of cancer, additional treatments may include radiation therapy to kill remaining cancer cells, chemotherapy for advanced or high-grade cancers, hormone therapy with progesterone to slow cancer growth, and targeted therapy or immunotherapy for specific cancer types. Early-stage endometrial cancer often requires only surgery, while advanced cases need combination treatments. Your treatment plan depends on cancer stage, type, overall health, and whether you want to preserve fertility.
How can I prevent endometrial cancer?
Maintaining a healthy weight is the most important prevention strategy since obesity increases estrogen production. Use birth control pills if appropriate, as they provide progesterone that protects the endometrial lining. If taking hormone replacement therapy, ensure it includes progesterone along with estrogen. Regular exercise, managing diabetes and PCOS, and maintaining hormonal balance reduce risk. Get regular gynecological checkups, report any abnormal bleeding immediately, and consider hormone level testing if you have risk factors. Eating a balanced diet rich in fruits and vegetables while limiting processed foods also supports hormonal health.
What natural remedies help with endometrial cancer prevention?
While natural approaches cannot treat cancer, certain lifestyle modifications support hormonal balance and may reduce risk. Maintain a healthy weight through regular exercise and a balanced diet, as excess body fat produces estrogen. Eat foods rich in phytoestrogens like flaxseeds and soy, which may help balance hormone levels. Increase intake of cruciferous vegetables like broccoli and cauliflower that support estrogen metabolism. Reduce alcohol consumption, manage stress through yoga or meditation, and ensure adequate sleep to support hormonal regulation. Always combine these natural approaches with regular medical checkups and appropriate screening, especially if you have risk factors.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Testosterone 375 ng/dL
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375 ng/dL

What this means

Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.

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* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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Estrogens (Total), Serum
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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