Encephalitis is inflammation of the brain tissue that can cause fever, confusion, seizures, and potentially life-threatening complications. It is most commonly caused by viral infections, particularly herpes simplex viruses (HSV-1 and HSV-2), West Nile virus, and enteroviruses. The Herpes Simplex Virus 2 (IgG) with Reflex to HSV-2 Inhibition test is the most important blood test for identifying HSV-2 as a potential cause of encephalitis.
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Encephalitis is caused by viral infections that attack and inflame brain tissue. The most common viral causes include herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), West Nile virus, enteroviruses, Japanese encephalitis virus, and arboviruses transmitted by mosquitoes and ticks. Less commonly, encephalitis can result from bacterial infections, autoimmune disorders where the immune system attacks the brain, or complications from vaccines. In many cases, the specific cause remains unidentified despite thorough testing.
The Herpes Simplex Virus 2 (IgG) with Reflex to HSV-2 Inhibition test is the most important blood test for encephalitis because it detects antibodies against HSV-2, a recognized viral cause of brain inflammation. While encephalitis diagnosis primarily relies on cerebrospinal fluid analysis obtained through lumbar puncture, MRI brain imaging, and clinical evaluation, blood tests play a crucial supporting role by identifying the specific viral infections responsible. High levels of HSV-2 IgG antibodies in patients with encephalitis symptoms can indicate HSV-2 as the causative agent, guiding antiviral treatment decisions. This test is particularly valuable because herpes simplex encephalitis requires immediate antiviral therapy to prevent severe neurological damage and death.
You should get tested immediately if you experience sudden high fever combined with severe headache, confusion, altered consciousness, seizures, or unusual behavior changes. Seek emergency medical attention if you notice stiff neck, sensitivity to light, difficulty speaking, loss of muscle control, or sudden personality changes, especially if you recently had a cold sore outbreak or tick bite. Early testing and diagnosis are critical because encephalitis is a medical emergency that can cause permanent brain damage or death without prompt antiviral treatment. Anyone with suspected brain inflammation symptoms requires immediate hospitalization for comprehensive evaluation including blood tests, brain imaging, and lumbar puncture.
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Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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