Edwards syndrome (Trisomy 18) is a genetic disorder caused by an extra copy of chromosome 18 that affects fetal development. It is caused by chromosomal nondisjunction during cell division, resulting in three copies of chromosome 18 instead of two. The Estriol LC/MS/MS Serum test is the most important prenatal blood screening for assessing Edwards syndrome risk during pregnancy.
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Edwards syndrome is caused by an extra copy of chromosome 18, which occurs due to a random error during the formation of egg or sperm cells. This chromosomal abnormality, called trisomy 18, happens when cells divide incorrectly and create reproductive cells with an extra chromosome. When fertilization occurs with these cells, the developing baby has three copies of chromosome 18 in every cell instead of the normal two, disrupting normal development and causing severe physical and intellectual disabilities.
The Estriol LC/MS/MS Serum test is the most important blood screening for Edwards syndrome because it measures estriol hormone levels that are typically reduced when a fetus has trisomy 18. This test is part of prenatal screening panels and helps identify pregnancies at higher risk that may need further diagnostic testing. While blood screening indicates risk levels, definitive diagnosis requires genetic testing through amniocentesis or chorionic villus sampling (CVS), which directly analyzes fetal chromosomes. The estriol test is valuable because it is non-invasive and can be performed early in pregnancy to guide decisions about additional testing.
You should get tested if you are pregnant and want to assess your baby's risk for chromosomal abnormalities, especially if you are over age 35, have a family history of genetic disorders, or have abnormal ultrasound findings. Prenatal screening with estriol testing is typically performed during the second trimester between weeks 15-20 of pregnancy. Testing is also recommended if you have had a previous pregnancy affected by Edwards syndrome or other chromosomal conditions, as early detection allows for informed decision-making and appropriate pregnancy management.
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What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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