Drug Hypersensitivity Syndrome is a severe, potentially life-threatening immune reaction to certain medications that affects multiple organ systems. It is caused by specific genetic variations in HLA (Human Leukocyte Antigen) genes, particularly HLA-B*5701, which trigger immune responses to medications like abacavir and carbamazepine. The HLA-A, B, C, DRB1 and DQ High Resolution test is the most important test for identifying individuals at risk before medication exposure.
90-day money-back guarantee
Lab order in minutes
Save a trip to the doctor
Low prices since 2005
Labs within 2 miles
Drug Hypersensitivity Syndrome is caused by specific genetic variations in your HLA (Human Leukocyte Antigen) genes that make your immune system overreact to certain medications. The HLA-B*5701 variant is particularly important because it causes severe reactions to medications like abacavir (used for HIV treatment), carbamazepine (for seizures), and allopurinol (for gout). When someone with these genetic markers takes triggering medications, their immune system mistakenly identifies the drug as dangerous and launches an aggressive attack that affects the skin, liver, kidneys, and other organs. This reaction typically develops within 2-6 weeks of starting the medication and can be life-threatening if not caught early.
The HLA-A, B, C, DRB1 and DQ High Resolution test is the most important test for Drug Hypersensitivity Syndrome because it identifies the specific genetic markers that predict severe reactions before you ever take a risky medication. This comprehensive genetic screening detects HLA-B*5701 and other high-risk variants that are strongly associated with hypersensitivity to medications including abacavir, carbamazepine, allopurinol, and certain antibiotics. The test requires a simple blood sample and provides permanent results since your genetics never change. If you test positive for HLA-B*5701 or other risk variants, your doctor can prescribe safer alternative medications, preventing potentially fatal reactions. This is especially crucial for people starting HIV treatment, anti-seizure medications, or gout medications where hypersensitivity reactions are most common and severe.
You should get tested before starting any medication known to cause hypersensitivity reactions, particularly if you are beginning HIV treatment with abacavir, anti-seizure medications like carbamazepine, or gout medications like allopurinol. Testing is especially important if you have a personal or family history of severe drug reactions, unexplained rashes after starting medications, or belong to ethnic groups with higher rates of HLA-B*5701 (certain Asian, African, and Hispanic populations). If you have previously experienced fever, rash, or organ problems within weeks of starting a new medication, genetic testing can identify whether you are at risk for future reactions. Since the test results are permanent and your genetics never change, getting tested once provides lifelong guidance for safe medication choices.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
505 reviews
Sample results
Your 24/7 Lab Guide
Quick questions:
