Deep Vein Thrombosis (DVT) Blood Test

What is Deep Vein Thrombosis (DVT)?

Deep Vein Thrombosis (DVT) is a condition where blood clots form in deep veins, typically in the legs. It is caused by genetic mutations like Factor V Leiden, protein C or antithrombin III deficiencies, or elevated clotting factors that create a hypercoagulable state. The Factor V Leiden Mutation Analysis is the most important test for DVT risk assessment because it identifies the most common inherited clotting disorder.

RECOMMENDED TEST Factor V (Leiden) Mutation Analysis
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What causes deep vein thrombosis?

Deep vein thrombosis is caused by genetic mutations like Factor V Leiden, deficiencies in natural anticoagulants such as protein C, protein S, and antithrombin III, or elevated levels of clotting factors like fibrinogen and prothrombin. These inherited or acquired conditions create a hypercoagulable state where blood clots too easily. Additional risk factors include prolonged immobility, surgery, pregnancy, birth control pills, smoking, obesity, and certain cancers that increase clotting tendency.

What is the best test for deep vein thrombosis?

The Factor V Leiden Mutation Analysis is the most important genetic test for DVT risk because it identifies the most common inherited clotting disorder, affecting about 5% of Caucasians. This test detects a specific mutation that makes blood five to ten times more likely to clot abnormally. Additional essential tests include Protein C Activity, Antithrombin III Antigen, Fibrinogen Activity, and Prothrombin (Factor II) testing, which together provide a comprehensive clotting risk profile. These blood tests identify whether you have inherited or acquired conditions that predispose you to dangerous blood clots, allowing for preventive strategies and informed treatment decisions.

When should I get tested for DVT risk?

You should get tested if you have a family history of blood clots, have experienced an unexplained DVT or pulmonary embolism, suffered multiple miscarriages, or have a blood clot at a young age (under 50). Testing is also important before starting birth control pills if you have a family history of clotting disorders, before major surgery if you have risk factors, or if you are planning pregnancy and have a personal or family history of clotting issues. Early identification of clotting disorders allows your doctor to implement preventive measures like anticoagulant therapy during high-risk situations.

What are the symptoms of deep vein thrombosis?
DVT symptoms typically appear in one leg and include swelling, pain or tenderness (often starting in the calf), warmth in the affected area, and red or discolored skin. The leg may feel heavy or achy, especially when standing or walking. Some people experience visible enlarged veins near the skin surface. However, about half of DVT cases produce no noticeable symptoms at all, which makes it particularly dangerous. If a clot breaks loose and travels to the lungs causing a pulmonary embolism, you may experience sudden shortness of breath, chest pain, rapid heartbeat, or coughing up blood, which requires immediate emergency care.
Who is at risk for deep vein thrombosis?
People at highest risk include those with inherited clotting disorders like Factor V Leiden mutation, anyone with prolonged immobility from long flights or bed rest, individuals recovering from surgery (especially orthopedic procedures), pregnant women and new mothers, and people taking hormone therapy or birth control pills. Additional risk factors include age over 60, obesity, smoking, cancer and cancer treatment, heart failure, inflammatory bowel disease, and a personal or family history of DVT or pulmonary embolism. Having multiple risk factors significantly increases your likelihood of developing blood clots.
What happens if DVT is left untreated?
Untreated DVT can lead to life-threatening pulmonary embolism, where a blood clot breaks free and travels to the lungs, blocking blood flow and potentially causing death. About 30% of people with untreated DVT develop pulmonary embolism within three months. Long-term complications include post-thrombotic syndrome, which occurs in up to 50% of DVT patients and causes chronic leg pain, swelling, skin discoloration, and ulcers that significantly impact quality of life. Early detection through risk assessment blood tests and prompt treatment with anticoagulants can prevent these serious complications and save lives.
Can DVT be diagnosed with a blood test?
DVT itself is diagnosed with imaging studies like ultrasound, not blood tests. However, blood tests are essential for assessing your risk of developing DVT by identifying inherited clotting disorders and measuring clotting factors. A D-dimer blood test can help rule out active clots when DVT is suspected, but genetic tests like Factor V Leiden Mutation Analysis, Protein C Activity, Antithrombin III Antigen, and other coagulation studies reveal your underlying predisposition to blood clots. These tests guide prevention strategies, help determine the need for anticoagulation therapy, and inform treatment duration decisions.
How is deep vein thrombosis treated?
DVT is treated primarily with anticoagulant medications (blood thinners) like warfarin, heparin, or newer direct oral anticoagulants (DOACs) such as rivaroxaban or apixaban, which prevent existing clots from growing and reduce the risk of new clots forming. Treatment typically lasts three to six months or longer for recurrent clots or inherited clotting disorders. Compression stockings help reduce swelling and prevent post-thrombotic syndrome. In severe cases, doctors may use clot-dissolving drugs (thrombolytics) or surgical procedures to remove large, dangerous clots. Your blood test results showing genetic or acquired clotting disorders will influence treatment duration and intensity.
How can I prevent deep vein thrombosis?
Prevention strategies include staying active and avoiding prolonged sitting or bed rest, moving your legs and ankles regularly during long flights or car trips, staying well-hydrated, maintaining a healthy weight, and quitting smoking. If you have known clotting disorders identified through blood tests, your doctor may prescribe preventive anticoagulants before surgery or during pregnancy. Wearing compression stockings during long travel helps maintain blood flow. After surgery, early mobilization and leg exercises are crucial. If you have multiple risk factors or inherited clotting disorders, discuss prophylactic blood thinners with your healthcare provider for high-risk situations.
What can I do at home for DVT prevention?
At home, practice regular leg exercises like ankle pumps and calf stretches, especially if you sit for long periods at work. Elevate your legs when resting to improve circulation. Stay hydrated by drinking plenty of water throughout the day. Avoid crossing your legs for extended periods, which restricts blood flow. Wear loose-fitting clothing that does not constrict your legs or waist. If you have been diagnosed with a clotting disorder through blood testing, wear prescribed compression stockings as directed. Maintain a heart-healthy diet rich in fruits, vegetables, and omega-3 fatty acids, and engage in regular physical activity like walking or swimming to keep blood flowing properly.
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Just reach out to us via text at 754-799-7833 or shoot us an email at support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Factor V (Leiden) Mutation Analysis
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What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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