Cystic fibrosis-related diabetes (CFRD) is a unique type of diabetes that develops in people with cystic fibrosis, affecting up to 50% of adults with CF. It is caused by thick mucus blocking the pancreas and preventing insulin production, combined with increased insulin resistance during CF lung infections. The Hemoglobin A1c with eAG Estimation is the most important test for monitoring CFRD because it tracks average blood glucose control over 2-3 months.
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Cystic fibrosis-related diabetes is caused by thick, sticky mucus that blocks the pancreas and damages insulin-producing cells over time. In CF, the defective CFTR protein causes mucus to accumulate in the pancreas, leading to scarring and destruction of both the cells that produce digestive enzymes and the beta cells that make insulin. Unlike Type 1 diabetes where the immune system attacks insulin cells, or Type 2 where the body becomes resistant to insulin, CFRD develops because the pancreas physically cannot produce enough insulin due to CF-related damage.
The Hemoglobin A1c with eAG Estimation is the most important test for monitoring cystic fibrosis-related diabetes because it measures your average blood glucose control over the past 2-3 months. This test shows what percentage of your hemoglobin has glucose attached to it, and the eAG number translates this into an average glucose reading you can compare with your daily meter checks. For people with CF, keeping your A1c in a healthy range is essential because good glucose control helps maintain lung function and nutritional status, which are critical for overall CF health. Your CF care team will use this test regularly to adjust your insulin or other treatments and prevent complications that could further impact your breathing and nutrition.
You should get tested if you have cystic fibrosis and notice unexplained weight loss, increased thirst or urination, or declining lung function despite good CF care. Annual diabetes screening is recommended starting at age 10 for all CF patients, but you should test sooner if you experience frequent respiratory infections that are harder to recover from, fatigue that interferes with daily activities, or if you are taking medications like corticosteroids that can raise blood sugar. Getting tested regularly helps catch CFRD early so you can start treatment before it impacts your lung health and nutritional status.
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What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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