CMV Mononucleosis Blood Test

What is CMV Mononucleosis?

CMV mononucleosis is a viral infection that causes fatigue, fever, sore throat, and swollen lymph nodes similar to infectious mononucleosis. It is caused by cytomegalovirus (CMV), a common herpes virus that spreads through bodily fluids like saliva, blood, and urine. The Cytomegalovirus (CMV) Antibodies, IgM, Quantitative test is the most important test for diagnosis because it detects active or recent CMV infection.

RECOMMENDED TEST Cytomegalovirus (CMV) Antibodies, IgM, Quantitative
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What causes CMV mononucleosis?

CMV mononucleosis is caused by cytomegalovirus (CMV), a member of the herpes virus family. The virus spreads through close contact with infected bodily fluids including saliva, blood, urine, semen, breast milk, and tears. You can contract CMV through kissing, sharing utensils or drinks, sexual contact, blood transfusions, or organ transplants from an infected person. Once infected, the virus remains dormant in your body for life and can reactivate when your immune system is weakened.

What is the best test for CMV mononucleosis?

The Cytomegalovirus (CMV) Antibodies, IgM, Quantitative test is the most important test for CMV mononucleosis because it detects IgM antibodies that appear early during active or recent CMV infection. This test measures specific antibody levels in your blood and distinguishes CMV mononucleosis from other causes of mono-like symptoms, particularly Epstein-Barr virus (EBV) infection. High levels of CMV IgM antibodies combined with typical mononucleosis symptoms confirm the diagnosis and help your healthcare provider determine the most appropriate treatment approach for your specific infection.

When should I get tested for CMV mononucleosis?

You should get tested if you have prolonged fatigue, fever, sore throat, and swollen lymph nodes that last more than a week, especially if you tested negative for Epstein-Barr virus but still have mono-like symptoms. Testing is also important if you are pregnant and develop these symptoms, as CMV can affect your baby, or if you have a weakened immune system from HIV, organ transplant, or chemotherapy. Get tested immediately if you experience severe fatigue that interferes with daily activities, persistent fever above 101°F, or swollen lymph nodes that do not improve after two weeks.

What are the symptoms of CMV mononucleosis?
CMV mononucleosis symptoms include extreme fatigue that can last for weeks or months, high fever (often above 100°F), severe sore throat, and swollen lymph nodes in the neck and armpits. You might also experience muscle aches, headaches, loss of appetite, night sweats, and enlarged spleen or liver. Unlike EBV mononucleosis, CMV mono rarely causes the severe throat inflammation with white patches. Most healthy people with CMV mononucleosis recover completely within 2-6 weeks, though fatigue may persist longer.
Who is at risk for CMV mononucleosis?
Young adults and teenagers are at highest risk for developing symptomatic CMV mononucleosis, particularly those in close-contact environments like college dormitories. People with weakened immune systems from HIV, organ transplants, chemotherapy, or immunosuppressive medications face greater risk of severe CMV infection. Pregnant women who contract CMV for the first time during pregnancy risk transmitting the virus to their unborn baby. Healthcare workers, daycare employees, and people who work with young children have increased exposure to CMV through contact with saliva, urine, and other bodily fluids.
What happens if CMV mononucleosis is left untreated?
Most healthy people recover from CMV mononucleosis without treatment, though symptoms may last several weeks. However, untreated CMV in people with weakened immune systems can lead to serious complications including pneumonia, hepatitis, inflammation of the brain (encephalitis), gastrointestinal ulcers, and vision problems from retinal infection. In pregnant women, untreated CMV can transmit to the baby and cause congenital CMV infection, potentially resulting in hearing loss, vision problems, developmental delays, and seizures in the newborn. Early detection through blood testing helps identify high-risk cases that need antiviral treatment.
Can CMV mononucleosis be diagnosed with a blood test?
Yes, CMV mononucleosis is definitively diagnosed with blood tests that detect CMV-specific antibodies. The CMV IgM antibody test identifies active or recent infection by measuring the first antibodies your immune system produces in response to the virus. Blood tests are essential because CMV mononucleosis symptoms are identical to other causes of mono, particularly Epstein-Barr virus infection, making it impossible to distinguish based on symptoms alone. Your doctor may also order a CMV IgG antibody test to determine if you have had a past infection, as IgG antibodies remain in your blood for life after CMV exposure.
How is CMV mononucleosis treated?
Most healthy people with CMV mononucleosis do not require specific antiviral treatment and recover with supportive care including plenty of rest, staying hydrated, and taking over-the-counter pain relievers like acetaminophen or ibuprofen for fever and discomfort. Avoid contact sports and heavy lifting for at least one month to prevent rupturing an enlarged spleen. People with weakened immune systems or severe infections may need antiviral medications like ganciclovir, valganciclovir, or foscarnet administered under close medical supervision. Pregnant women with CMV may receive hyperimmune globulin therapy to reduce the risk of transmission to the baby.
How can I prevent CMV mononucleosis?
Prevent CMV transmission by washing your hands frequently with soap and water for at least 20 seconds, especially after contact with saliva, urine, or other bodily fluids from young children or people who might be infected. Avoid sharing drinks, utensils, food, toothbrushes, or lipstick with others. Do not kiss people on the mouth if you or they might have CMV. Practice safe sex by using condoms to reduce transmission through sexual contact. Pregnant women should be particularly careful when caring for young children by wearing gloves during diaper changes and avoiding contact with saliva. Healthcare workers should follow standard infection control precautions when handling blood and body fluids.
What natural remedies help with CMV mononucleosis?
Support your recovery from CMV mononucleosis by getting adequate sleep and rest, as your body needs extra energy to fight the infection. Stay well-hydrated by drinking plenty of water, herbal teas, and warm liquids like chicken soup to soothe your sore throat. Eat nutritious foods rich in vitamins C and D, zinc, and antioxidants to support immune function, including citrus fruits, leafy greens, berries, nuts, and lean proteins. Gargle with warm salt water several times daily to relieve throat pain. Use a humidifier in your bedroom to ease breathing and throat discomfort. Avoid alcohol and limit physical activity until your symptoms resolve completely to prevent complications and speed recovery.
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Cytomegalovirus (CMV) Antibodies, IgM, Quantitative
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
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No extra fees paid at the lab

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