Chronic Hives Blood Test

What is Chronic Urticaria?

Chronic urticaria is a condition where raised, itchy welts (hives) appear on the skin and persist for six weeks or longer. It is caused by histamine release from mast cells in the skin, which triggers inflammation and swelling. The Histamine Release (Chronic Urticaria) test is the most important test for diagnosis because it directly measures mast cell activity.

RECOMMENDED TEST Histamine Release (Chronic Urticaria)
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What causes chronic hives?

Chronic hives are caused by histamine release from mast cells in your skin, which triggers inflammation and swelling. This histamine release can be triggered by allergens like pet dander, certain foods, medications, stress, temperature changes, or infections. In many cases, the exact trigger remains unknown, which is why chronic urticaria is sometimes called idiopathic urticaria, but identifying potential allergens through testing can help you manage and avoid triggers that worsen your symptoms.

What is the best test for chronic hives?

The Histamine Release (Chronic Urticaria) test is the most important test for chronic hives because it directly measures how much histamine your mast cells are releasing, which is the primary mechanism causing your welts and itching. This test confirms whether your symptoms are histamine-mediated and helps guide treatment decisions. Additionally, the Histamine, Plasma test measures circulating histamine levels to assess overall histamine activity in your system, while specific allergy tests like the Cat Epithelium/Dander (e1) IgG can identify particular triggers such as pet allergens that may be causing your recurring hives.

When should I get tested for chronic hives?

You should get tested if you have been experiencing recurring hives or welts that last for more than six weeks, if your hives are interfering with your daily activities or sleep due to intense itching, or if you suspect certain triggers like pet exposure or specific foods are causing your outbreaks. Testing is especially important if over-the-counter antihistamines are not providing relief or if you want to identify specific allergens to avoid. Getting tested early can help you develop a targeted treatment plan and improve your quality of life by pinpointing avoidable triggers.

What are the symptoms of chronic hives?
The main symptoms of chronic hives include raised, red or skin-colored welts that appear anywhere on your body, intense itching that often worsens at night, and swelling of the skin that comes and goes unpredictably. Individual hives may last for a few hours before fading, but new ones continue to appear for weeks or months. Some people also experience angioedema, which is deeper swelling in areas like the lips, eyelids, or throat, and the welts may change shape or location throughout the day.
Who is at risk for chronic hives?
Anyone can develop chronic hives, but they are more common in adults between ages 30 and 50, and women are affected twice as often as men. People with allergies, autoimmune conditions like thyroid disease or lupus, or a family history of hives have a higher risk. Those who have frequent exposure to common triggers like stress, certain medications (especially NSAIDs or antibiotics), extreme temperatures, or infections are also more susceptible to developing chronic urticaria.
What happens if chronic hives are left untreated?
If left untreated, chronic hives can significantly impact your quality of life by causing persistent itching, sleep disturbances, and emotional stress from the unpredictable appearance of welts. While chronic hives are not typically life-threatening, severe cases can lead to angioedema with swelling in the throat that may affect breathing and require emergency treatment. Untreated chronic urticaria can also lead to skin damage from constant scratching, secondary infections, anxiety, and depression from dealing with a chronic condition that affects your appearance and comfort.
Can chronic hives be diagnosed with a blood test?
Chronic hives are primarily diagnosed based on your symptoms and medical history through a clinical examination, but blood tests play a crucial role in confirming the diagnosis and identifying triggers. The Histamine Release test and Histamine, Plasma test can confirm that histamine from mast cells is causing your symptoms, while specific IgG and IgE allergy tests can identify allergens like pet dander, foods, or environmental triggers. Blood tests may also check for underlying conditions like thyroid problems or autoimmune diseases that can contribute to chronic urticaria.
How is chronic hives treated?
Chronic hives are typically treated with daily antihistamines to block histamine and prevent welts from forming, with higher doses sometimes needed for stubborn cases. If antihistamines alone do not work, your doctor may prescribe omalizumab (Xolair), an injectable medication that reduces IgE antibodies and mast cell activity, or other immune-modulating medications like cyclosporine or corticosteroids for short-term use. Identifying and avoiding specific triggers through allergy testing is also a key part of treatment, and working with your healthcare provider to develop a personalized management plan can help control symptoms and improve your quality of life.
How can I prevent chronic hives?
Preventing chronic hives starts with identifying and avoiding your specific triggers through allergy testing and keeping a symptom diary. Common prevention strategies include managing stress through relaxation techniques, avoiding known allergens like certain foods or pet dander, wearing loose-fitting clothing to reduce skin irritation, and avoiding extreme temperatures or rapid temperature changes. You should also be cautious with medications like aspirin and NSAIDs that can trigger hives, avoid alcohol which can worsen symptoms, and maintain a consistent antihistamine routine as prescribed by your doctor even when you are not having an outbreak.
What natural remedies help with chronic hives?
Natural remedies that may help manage chronic hives include applying cool compresses or taking cool baths with colloidal oatmeal to soothe itching and reduce inflammation, and wearing loose, breathable cotton clothing to minimize skin irritation. Some people find relief by taking quercetin or vitamin C supplements, which have natural antihistamine properties, though you should consult your doctor before starting any supplements. Stress reduction techniques like meditation, yoga, or deep breathing exercises can help since stress is a common trigger, and avoiding hot showers, tight clothing, and scratching can prevent worsening of symptoms.
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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Histamine Release (Chronic Urticaria)
Google reviews 505 reviews
$654 $510
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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