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Chronic urticaria is a condition where raised, itchy welts (hives) appear on the skin and persist for six weeks or longer. It is caused by histamine release from mast cells in the skin, which triggers inflammation and swelling. The Histamine Release (Chronic Urticaria) test is the most important test for diagnosis because it directly measures mast cell activity.
Chronic hives are caused by histamine release from mast cells in your skin, which triggers inflammation and swelling. This histamine release can be triggered by allergens like pet dander, certain foods, medications, stress, temperature changes, or infections. In many cases, the exact trigger remains unknown, which is why chronic urticaria is sometimes called idiopathic urticaria, but identifying potential allergens through testing can help you manage and avoid triggers that worsen your symptoms.
The Histamine Release (Chronic Urticaria) test is the most important test for chronic hives because it directly measures how much histamine your mast cells are releasing, which is the primary mechanism causing your welts and itching. This test confirms whether your symptoms are histamine-mediated and helps guide treatment decisions. Additionally, the Histamine, Plasma test measures circulating histamine levels to assess overall histamine activity in your system, while specific allergy tests like the Cat Epithelium/Dander (e1) IgG can identify particular triggers such as pet allergens that may be causing your recurring hives.
You should get tested if you have been experiencing recurring hives or welts that last for more than six weeks, if your hives are interfering with your daily activities or sleep due to intense itching, or if you suspect certain triggers like pet exposure or specific foods are causing your outbreaks. Testing is especially important if over-the-counter antihistamines are not providing relief or if you want to identify specific allergens to avoid. Getting tested early can help you develop a targeted treatment plan and improve your quality of life by pinpointing avoidable triggers.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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