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Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung condition that causes airflow blockage and breathing difficulties. It is caused by long-term exposure to irritating gases or particulate matter, most often from cigarette smoke, or by Alpha-1-Antitrypsin deficiency, a genetic condition that damages the lungs. The Alpha-1-Antitrypsin Quantitative test is the most important blood test for COPD because it identifies this genetic cause that requires different treatment approaches.
COPD is caused primarily by long-term exposure to lung irritants that damage the lungs and airways, with cigarette smoking being the leading cause in about 85-90% of cases. Other causes include Alpha-1-Antitrypsin deficiency, a genetic condition where your body doesn't produce enough of a protective enzyme that shields lung tissue from damage. Additional risk factors include secondhand smoke exposure, workplace dust and chemicals, indoor air pollution from burning fuel for cooking and heating, and outdoor air pollution.
The Alpha-1-Antitrypsin Quantitative test is the most important blood test for COPD because it identifies the genetic deficiency that causes early-onset COPD, often before age 45, and helps determine if your family members should also be tested. This test measures the protective enzyme that prevents lung tissue breakdown, and low levels indicate you need specialized treatment approaches different from typical COPD management. Additional blood tests that support COPD assessment include the Carbon Dioxide test, which measures how well your lungs are removing CO2 from your blood and indicates disease severity, and the Myeloperoxidase test, which measures inflammation levels to help guide anti-inflammatory treatment decisions.
You should get tested if you experience persistent cough that lasts for months, shortness of breath especially during physical activities, wheezing or whistling sounds when breathing, or frequent chest tightness. Testing is especially important if you're a current or former smoker over age 40, have a family history of early-onset lung disease, or developed breathing problems at a younger age without significant smoking history. Get tested immediately if you notice your symptoms are getting worse, you're experiencing more frequent respiratory infections, or you're coughing up blood or discolored mucus.
What this means
Your testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, or lower muscle mass over time.
Recommended actions
Increase resistance or strength training
Prioritize 7–8 hours of quality sleep per night, try to reduce stress
Include more zinc- and magnesium-rich foods (like shellfish, beef, pumpkin seeds, spinach)
Consider retesting in 3–6 months
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