Behcet's Disease Blood Test

What is Behcet's Disease?

Behcet's Disease is a rare chronic inflammatory disorder that causes blood vessel inflammation throughout the body. It is caused by an autoimmune response where the immune system mistakenly attacks blood vessels, with genetic susceptibility linked to the HLA-B51 biomarker. The Cardiolipin Antibodies (IgA, IgG, IgM) test is the most important test for assessing vascular involvement and disease activity in Behcet's Disease.

RECOMMENDED TEST Cardiolipin Antibodies (IgA, IgG, IgM)
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What causes Behcet's Disease?

Behcet's Disease is caused by an autoimmune response where your immune system mistakenly attacks and inflames blood vessels throughout your body. While the exact trigger remains unclear, the condition has a strong genetic component, particularly in people who carry the HLA-B51 or HLA-B5 genetic marker. Environmental factors like viral or bacterial infections may also trigger the disease in people who are genetically predisposed.

What is the best test for Behcet's Disease?

The Cardiolipin Antibodies (IgA, IgG, IgM) test is the most important blood test for Behcet's Disease because it detects antibodies associated with vascular involvement and helps assess disease activity. The HLA-A, B, C, DRB1 and DQ High Resolution genetic test is also essential as it identifies the HLA-B51 marker, which indicates increased genetic susceptibility to the condition. Additional tests like Interleukin 17 Serum can measure inflammatory activity, while ASCA antibody tests help identify intestinal involvement. These tests work together to provide a comprehensive picture of disease activity and complications.

When should I get tested for Behcet's Disease?

You should get tested if you experience recurring mouth sores combined with other symptoms like genital ulcers, eye inflammation, or unusual skin rashes. Testing is also important if you have a family history of Behcet's Disease or are of Mediterranean, Middle Eastern, or East Asian descent and develop unexplained inflammatory symptoms. If you notice painful sores that keep coming back, vision problems, joint pain, or blood clots without obvious cause, these could be warning signs that warrant testing.

What are the symptoms of Behcet's Disease?
Behcet's Disease causes recurring painful mouth sores that look similar to canker sores and are often the first sign of the condition. Other common symptoms include genital ulcers, eye inflammation with redness and blurred vision, skin problems like acne-like sores or red tender nodules, and joint pain especially in the knees and ankles. Some people experience digestive issues with abdominal pain and diarrhea, blood clots in veins, and in severe cases, inflammation of the brain and nervous system causing headaches and confusion.
Who is at risk for Behcet's Disease?
People of Mediterranean, Middle Eastern, and East Asian descent are at higher risk for Behcet's Disease, with the highest rates found in Turkey, Iran, and Japan. The condition typically affects adults in their 20s and 30s, though it can occur at any age. Having the HLA-B51 genetic marker significantly increases your risk, and men tend to develop more severe symptoms than women. A family history of the disease also increases your likelihood of developing it.
What happens if Behcet's Disease is left untreated?
Untreated Behcet's Disease can lead to serious complications including permanent vision loss or blindness from repeated eye inflammation. Blood vessel damage can cause dangerous blood clots in veins and arteries, potentially leading to stroke or organ damage. The digestive system can develop ulcers and perforations requiring emergency surgery, while joint inflammation can become chronic and debilitating. In rare cases, inflammation can affect the brain and spinal cord, causing neurological problems like memory loss, balance issues, and stroke-like symptoms.
Can Behcet's Disease be diagnosed with a blood test?
Behcet's Disease cannot be diagnosed by a single blood test alone, as diagnosis relies primarily on clinical symptoms and established medical criteria. However, blood tests play an essential supporting role by identifying genetic susceptibility through HLA-B51 testing, measuring inflammatory markers like Interleukin 17, and detecting vascular complications through Cardiolipin Antibody testing. These tests help your doctor confirm the diagnosis, assess disease activity, rule out other conditions with similar symptoms, and monitor your response to treatment over time.
How is Behcet's Disease treated?
Behcet's Disease treatment focuses on reducing inflammation and preventing complications through medications tailored to your specific symptoms. Corticosteroids like prednisone quickly reduce inflammation during flare-ups, while immunosuppressive drugs like azathioprine or cyclosporine help control the overactive immune response for long-term management. Biologic medications such as TNF-alpha inhibitors are used for severe cases affecting the eyes or nervous system. Your doctor may also prescribe topical treatments for mouth and genital sores, and colchicine to help prevent skin lesions and joint pain.
How can I prevent Behcet's Disease flare-ups?
While you cannot prevent Behcet's Disease itself, you can reduce flare-ups by identifying and avoiding your personal triggers. Many people find that stress management through meditation, yoga, or regular exercise helps minimize symptoms. Maintaining good oral hygiene with a soft toothbrush and avoiding foods that irritate your mouth can reduce sores. Getting adequate sleep, eating an anti-inflammatory diet rich in fruits and vegetables, and avoiding tobacco are also important. Keep a symptom diary to identify your specific triggers and work closely with your doctor to adjust medications during high-risk periods.
What can I do at home for Behcet's Disease symptoms?
For mouth sores, rinse with warm salt water several times daily and avoid spicy, acidic, or rough foods that can irritate the lesions. Apply ice packs to swollen joints for 15-20 minutes to reduce pain and inflammation. For skin lesions, keep the area clean and avoid tight clothing that rubs against sores. A diet rich in omega-3 fatty acids from fish and flaxseed may help reduce inflammation naturally. Over-the-counter pain relievers like acetaminophen can help manage discomfort, but always consult your doctor before adding supplements or making significant changes to your treatment plan.
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If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.
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Cardiolipin Antibodies (IgA, IgG, IgM)
Google reviews 505 reviews
$398 $310
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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